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Tumor marker:- Part 14 – Summary of Tumor markers

April 9, 2023Lab TestsTumor marker

Tumor markers

Tumor markers are summarised:

Tumor marker Tumor diagnosis or association (origin of tumors)
  • ACTH
  1. Lung small cell carcinoma
  2. Cushing’s syndrome
  • AFP
  1. Liver cell carcinoma
  2. Stomach
  3. Colon
  4. Pancreas tumors
  • BRCA1 gene mutation
  1. Breast cancer
  2. Ovarian tumors
  • BTA
  • Urinary bladder tumor
  • CA 15-3
  1. Breast
  2. Ovary tumors
  • CA 19-9
  1. Liver
  2. G I tract
  • CA 19-5
  1. G I tract
  2. Pancreas
  3. Ovary
  • CA 125
  1. Ovary
  2. Endometrium
  • CA 549
  1. Breast
  2. Ovary
  • CA 27-29
  • Breast
  • CA 50
  1. Pancreas
  2. G I tract
  3. Colon
  • CA 72-4
  1. Ovary
  2. Breast
  3. G I tract
  • CA 242
  1. G I Tract
  2. Pancreas
  • Calcitonin
  • Medullary carcinoma of the thyroid
  • CEA
  1. Colon
  2. Liver
  3. Stomach
  4. Pancreas
  • c-erb B-2/Her-2
  1. Breast
  2. Ovary
  • ER/PR
  • Breast for hormone response
  • HCG
  • Germ cell tumors
  • Hydroxyproline (in urine)
  1. Bone metastasis (breast)
  2. Multiple Myeloma
  • VMA and HVA
  1. Neuroblastoma
  2. Pheochromocytoma
  • MCA
  1. Breast
  2. Ovary
  • M- protein and paraproteins
  • Multiple myeloma
  • PSA
  • Prostate
  • Serotonin
  1. Carcinoid tumors
  2. Oat cell carcinoma
  • tDT
  • leukemia
  • Philadelphia chromosome
  • Myelocytic leukemia
  • Polyamine (in CSF)
  • Brain tumors
  • Lipid-associated sialic acid
  1. Lung
  2. G I tract
Enzymes
  • Aldose
  • Liver
  • Alkaline phosphatase
  1. Bone
  2. Liver
  3. Sarcoma
  4. Leukemia
  • Amylase
  • Pancreas
  • Creatinine kinase-BB
  1. Prostate
  2. Small cell carcinoma lung
  3. Breast
  4. Colon
  5. Ovary
  • Esterase
  • breast
  • γ-GTT
  • Liver
  • LDH
  1. Liver
  2. Lymphoma
  3. Leukemias
  • Neuron-specific enolase
  1. Small cell carcinoma lung
  2. Neuroblastoma
  3. Carcinoid
  4. Melanoma
  5. Pancreas
  • Prostatic acid phosphatase
  • Prostate
  • Pyruvate kinase
  • Liver
  • Thymidine kinase
  1. Leukemias
  2. Lymphomas
  3. Small cell carcinoma lung
Oncofetal antigens 
  • AFP (glycoprotein)
  1. Liver cell carcinoma
  2. Germ cell  (nonseminoma) tumor
  • β-oncofetal antigen
  • Colon
  • Carcinofetal ferritin (glycoprotein)
  • Liver
  • CEA  (Glycoprotein)
  1. Colorectal (GItract)
  2. Pancreas
  3. Lung
  4. Breast
  • Pancreatic oncofetal antigen (glycoprotein)
  • Pancreas
  • Squamous cell antigen (glycoprotein)
  1. Cervix
  2. Skin
  3. Lung
  4. Head and neck squamous cell carcinoma
  • Tissue polypeptide antigen
  1. Colorectal
  2. Breast
  3. Urinary bladder
  • Tennesse antigen (glycoprotein)
  1. Colon
  2. Urinary bladder
  3. Ovary
Proteins as a tumor marker
  • β2-Microglobulin
  1. B- cell lymphoma
  2. Multiple Myeloma
  3. CLL
  4. Walden’s storm macroglobulinemia
  • C-peptide
  • Insulinoma
  • Ferritin
  1. Breast
  2. Liver
  3. Lung
  4. Leukemia
  • Immunoglobulins (M-protein)
  1. Multiple myeloma
  2. Lymphomas
  • Melanoma-associated antigen
  • Melanoma
  • Pancreas associated antigen
  1. Pancreas
  2. Stomach
  • Pregnancy-specific protein 1
  1. Trophoblastic tumors
  2. Germ cell tumor
  • Prothrombin precursor
  • Liver cell carcinoma
  • Tumor-associated trypsin inhibitor
  1. G I tract
  2. Lung
  3. Ovary

 

Possible References Used
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