Tumor marker:- Part 14 – Summary of Tumor markers for various tumors of the body
Tumor markers are summarised:
| Tumor marker | Tumor diagnosis or association (origin of tumors) |
| ACTH | Lung small cell carcinoma and Cushing’s syndrome |
| AFP | Liver cell carcinoma, stomach, colon, and pancreas tumors |
| BRCA1 gene mutation | Breast cancer and ovarian tumors |
| BTA | Urinary bladder tumor |
| CA 15-3 | Breast and ovary tumors |
| CA 19-9 | Liver and G I tract |
| CA 19-5 | G I tract, pancreas, and ovary |
| CA 125 | Ovary and endometrium |
| CA 549 | Breast, and ovary |
| CA 27-29 | Breast |
| CA 50 | Pancreas, G I tract, and colon |
| CA 72-4 | Ovary, Breast, and G I tract |
| CA 242 | G I Tract, and pancreas |
| Calcitonin | Medullary carcinoma of the thyroid |
| CEA | Colon, liver, stomach, and pancreas |
| c-erb B-2/Her-2 | Breast and ovary |
| ER/PR | Breast for hormone response |
| HCG | Germ cell tumors |
| Hydroxyproline (in urine) | Bone metastasis (breast), and M.Myeloma |
| VMA and HVA | Neuroblastoma and Pheochromocytoma |
| MCA | Breast and Ovary |
| M- protein and paraproteins | Multiple myeloma |
| PSA | Prostate |
| Serotonin | Carcinoid tumors, oat cell carcinoma |
| tDT | leukemia |
| Philadelphia chromosome | Myelocytic leukemia |
| Polyamine (in CSF) | Brain tumors |
| Lipid-associated sialic acid | Lung, and G I tract |
| Enzymes | |
| Aldose | Liver |
| Alkaline phosphatase | Bone, liver, sarcoma, and leukemia |
| Amylase | Pancreas |
| Creatinine kinase-BB | Prostate, small cell carcinoma lung, breast, colon, and ovary |
| Esterase | breast |
| γ-GTT | Liver |
| LDH | Liver, lymphoma, and leukemias |
| Neuron-specific enolase | Small cell carcinoma lung, neuroblastoma, carcinoid, melanoma, pancreas |
| Prostatic acid phosphatase | Prostate |
| Pyruvate kinase | Liver |
| Thymidine kinase | Leukemias, lymphomas, and small cell carcinoma lung |
| Oncofetal antigens | |
| AFP (glycoprotein) | Liver cell carcinoma and germ cell (nonseminoma) tumor |
| β-oncofetal antigen | Colon |
| Carcinofetal ferritin (glycoprotein) | Liver |
| CEA (Glycoprotein) | Colorectal (GItract), pancreas, lung, and breast |
| Pancreatic oncofetal antigen (glycoprotein) | Pancreas |
| Squamous cell antigen (glycoprotein) | Cervix, skin, lung, head, and neck squamous cell carcinoma |
| Tissue polypeptide antigen | Colorectal, breast, and urinary bladder |
| Tennesse antigen (glycoprotein) | Colon, urinary bladder, and ovary |
| Proteins as a tumor marker | |
| β2-Microglobulin | B- cell lymphoma, M.Myeloma, CLL, and Walden’s storm macroglobulinemia |
| C-peptide | Insulinoma |
| Ferritin | Breast, liver, lung, and leukemia |
| Immunoglobulins (M-protein) | Multiple myeloma, and lymphomas |
| Melanoma-associated antigen | Melanoma |
| Pancreas associated antigen | Pancreas, and stomach |
| Pregnancy-specific protein 1 | Trophoblastic tumors, and germ cell tumor |
| Prothrombin precursor | Liver cell carcinoma |
| Tumor-associated trypsin inhibitor | G I tract, lung, and ovary |