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Tumor marker:- Part 14 – Summary of Tumor markers for various tumors of the body

May 3, 2021Lab TestsTumor marker

Tumor markers are summarised:

Tumor marker Tumor diagnosis or association (origin of tumors)
ACTH Lung small cell carcinoma and Cushing’s syndrome
AFP Liver cell carcinoma, stomach, colon, and pancreas tumors
BRCA1 gene mutation Breast cancer and ovarian tumors
BTA Urinary bladder tumor
CA 15-3 Breast and ovary tumors
CA 19-9 Liver and G I tract
CA 19-5 G I tract, pancreas, and ovary
CA 125 Ovary and endometrium
CA 549 Breast, and ovary
CA 27-29 Breast
CA 50 Pancreas, G I tract, and colon
CA 72-4 Ovary, Breast, and G I tract
CA 242 G I Tract, and pancreas
Calcitonin Medullary carcinoma of the thyroid
CEA Colon, liver, stomach, and pancreas
c-erb B-2/Her-2 Breast and ovary
ER/PR Breast for hormone response
HCG Germ cell tumors
Hydroxyproline (in urine) Bone metastasis (breast), and M.Myeloma
VMA and HVA Neuroblastoma and Pheochromocytoma
MCA Breast and Ovary
M- protein and paraproteins Multiple myeloma
PSA Prostate
Serotonin Carcinoid tumors, oat cell carcinoma
tDT leukemia
Philadelphia chromosome Myelocytic leukemia
Polyamine (in CSF) Brain tumors
Lipid-associated sialic acid Lung,  and G I tract
Enzymes
Aldose Liver
Alkaline phosphatase Bone, liver, sarcoma, and leukemia
Amylase Pancreas
Creatinine kinase-BB Prostate, small cell carcinoma lung, breast, colon, and ovary
Esterase breast
γ-GTT Liver
LDH Liver, lymphoma, and leukemias
Neuron-specific enolase Small cell carcinoma lung, neuroblastoma, carcinoid, melanoma, pancreas
Prostatic acid phosphatase Prostate
Pyruvate kinase Liver
Thymidine kinase Leukemias, lymphomas, and small cell carcinoma lung
Oncofetal antigens 
AFP (glycoprotein) Liver cell carcinoma and germ cell  (nonseminoma) tumor
β-oncofetal antigen Colon
Carcinofetal ferritin (glycoprotein) Liver
CEA  (Glycoprotein) Colorectal (GItract), pancreas, lung, and breast
Pancreatic oncofetal antigen (glycoprotein) Pancreas
Squamous cell antigen (glycoprotein) Cervix,  skin, lung, head, and neck squamous cell carcinoma
Tissue polypeptide antigen Colorectal, breast, and urinary bladder
Tennesse antigen (glycoprotein) Colon, urinary bladder, and ovary
Proteins as a tumor marker
β2-Microglobulin B- cell lymphoma, M.Myeloma, CLL, and Walden’s storm macroglobulinemia
C-peptide Insulinoma
Ferritin Breast, liver, lung, and leukemia
Immunoglobulins (M-protein) Multiple myeloma, and lymphomas
Melanoma-associated antigen Melanoma
Pancreas associated antigen Pancreas, and stomach
Pregnancy-specific protein 1 Trophoblastic tumors, and germ cell tumor
Prothrombin precursor Liver cell carcinoma
Tumor-associated trypsin inhibitor G I tract, lung, and ovary

 

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