HealthFlex
×
  • Home
  • Immunology Book
  • Lab Tests
    • Hematology
    • Fluid analysis
    • CSF
    • Urine Analysis
    • Chemical pathology
    • Blood banking
    • Fungi
    • General pathology
    • Immune system
    • Microbiology
    • Parasitology
    • Pathology
    • Tumor marker
    • Virology
    • Cytology
  • Lectures
    • Bacteriology
    • Liver
    • Lymph node
    • Mycology
    • Virology
  • Blog
    • Economics and technical
    • Fitness health
    • Mental health
    • Nutrition
    • Travel
    • Preventive health
    • Nature and photos
    • General topic
  • Medical Dictionary
  • About Us
  • Contact

Rotor’s Syndrome

September 27, 2020Chemical pathologyLab Tests

Sample

  1. The serum of the patient is needed.
  2. The urine sample can be used.

Precautions

  1. Avoid the hemolyzed sample.
  2. Avoid lipemic serum.
  3. Avoid serum from the light.
  4. Avoid urine from exposure to light.

Pathophysiology

  1. This is a rare, relatively benign (mild) autosomal recessive disease of the liver.
  2. This is similar to Dubin-Johnson syndrome and both lead to increase conjugated (direct) bilirubin.
Rotor's Syndrome Mechanism

Rotor’s Syndrome Mechanism

  1. There is an impairment of excretion of bilirubin from hepatocytes into the bile canalicular lumen.
Rotor's Syndrome Mechanism

Rotor’s Syndrome Mechanism

  1. This causes defective:
    1. Excretion of conjugated bilirubin.
    2. It’s reabsorption into the blood.
    3. Excretion in the urine.
  2. The difference of Rotor’s syndrome from the Dubin-Johnson syndrome is:
    1. There is no hepatic pigmentation.
    2. Oral Cholecystography also differentiates which is normal in this condition.
    3. Ultrasound shows no abnormality.
    4. Liver biopsy shows no pigmentation.

Signs and symptoms

  1. This disease is usually seen in infancy or childhood.
  2. There is chronic jaundice without any evidence of hemolysis.
  3. Sometimes these patients may have intermittent epigastric discomfort and abdominal pain.
  4. There may be an attack of fever.

Diagnosis

  1. There is jaundice with increased conjugated bilirubinemia.
  2. Liver biopsy is normal in histology.
  3. The gallbladder can be visualized by cholecystography. This differentiates it from Dubin-Johnson syndrome.

Treatment

  • This is a benign disease and no active intervention needed unless there is some other cause of liver disease.

Possible References Used
Go Back to Chemical pathology

Add Comment Cancel


  • Lab Tests
    • Blood banking
    • Chemical pathology
    • CSF
    • Cytology
    • Fluid analysis
    • Fungi
    • General pathology
    • Hematology
    • Immune system
    • Microbiology
    • Parasitology
    • Pathology
    • Tumor marker
    • Urine Analysis
    • Virology

About Us

Labpedia.net is non-profit health information resource. All informations are useful for doctors, lab technicians, nurses, and paramedical staff. All the tests include details about the sampling, normal values, precautions, pathophysiology, and interpretation.

[email protected]

Quick Links

  • Blog
  • About Us
  • Contact
  • Disclaimer

Our Team

Professor Dr. Riaz Ahmad Bhutta

Dr. Naheed Afroz Syed

Dr. Asad Ahmad, M.D.

Dr. Shehpar Khan, M.D.

Copyright © 2014 - 2023. All Rights Reserved.
Web development by Farhan Ahmad.