Mean Corpuscular Hemoglobin (MCH), Mean Cell Hemoglobin
Mean Corpuscular Hemoglobin
Sample for Mean Corpuscular Hemoglobin
- This test is done on blood in EDTA (anticoagulant).
Indication for Mean Corpuscular Hemoglobin
- It is done as part of blood indices.
- It is done to diagnose anemia. It has limited value in diagnosing anemia.
Precaution for Mean Corpuscular Hemoglobin
- Keep in mind that the abnormal size of the RBC may affect the value.
- The presence of cold agglutinins gives a false raised value.
- Raised WBC count also affects the value.
Definition of Mean corpuscular hemoglobin (MCH)
- Mean corpuscular hemoglobin (MCH) is obtained by dividing hemoglobin by RBC count.
- It represents the average amount of hemoglobin/RBCs.
Mean Corpuscular Hemoglobin (MCH) Calculation
- This is the mean of the weight of average hemoglobin in one RBC.
- MCH and MCHC values are used to determine the hemoglobin contents in the RBCs.
- MCH adds very little value to other blood indices.
|18 to 20 weeks||43.14 ± 2.7|
|21 to 22 weeks||41.39 ± 3.32|
|23 to 25 weeks||40.48 ± 2.88|
|26 to 30 weeks||37.04 ± 3.67|
|Infants and Child|
|Cord blood||31 to 37|
|0.5 month||30 to 37|
|0ne month||29 to 36|
|2 month||27 to 34|
|4 month||25 to 32|
|6 month||24 to 30|
|9 month||25 to 30|
|12 month||24 to 30|
|1 to 2 year||22 to 30|
|3 to 5 year||25 to 31|
|6 to 8 year||25 to 31|
|9 to 11 year||26 to 32|
|12 to 14 year||26 to 32||26 to 32|
|15 to 17 year||27 to 32||26 to 34|
|18 to 44 year||27 to 37||27 to 34|
|45 to 64 year||27 to 35||27 to 34|
|65 to 74 year||27to 34||27 to 35|
- Adult = 27 to 31 pg (picogram).
- Newborn = 32 to 34 pg (picogram)
- 26 to 34 pg
Interference for estimation of Mean Corpuscular Hemoglobin (MCH):
- Cold agglutinins.
- Increased white blood cells (Leucocytosis = >50,000/cmm).
- In vivo hemolysis.
- In case of high concentration of heparin.
- Monoclonal proteins in the blood.
Increased Mean corpuscular hemoglobin (MCH) is seen in the following:
- Macrocytic anemia and in newborns.
- Infants and newborns.
Decreased Mean Corpuscular Hemoglobin (MCH) is seen in:
- Microcytic anemia.
- Hypochromic anemia.
Questions and answers:
Question 1: What is the value of MHC for the diagnosis of anemia?
MHC has little value for the diagnosis of anemia.
Question 2: What is an effect of hemolysis on MCH?
Hemolysis interferes with the estimation of MCH.