Viral Hepatitis Markers, Hepatotropic Viruses Summary

Viral hepatitis Markers

Sample

1. These tests are done in the serum of the patients.
2. Various viral markers for the diagnosis of viral hepatitis.

Viral Hepatitis	Route of transmission	Antigen / Antibody	Appear (incubation period)	Antigen/Antibody Disappears	Virus structure	Stage of Disease
Hepatitis A	Feco-oral and sexual	HAV-IgM	4 to 6 weeks	3 to 4 months	27-nm RNA virus	Acute infection
		HAV-IgA	8 to 12 weeks	10 years		Previous infection
Hepatitis B	Parenteral, sexual	HBsAg	4 to 12 weeks	1 to 3 months	42-nm DNA virus	Acute HBV infection
		HBsAb	3 to 4 months	6 to 10 years		Immunity to HBV infection
		HBeAg	1 to 3 weeks	6 to 8 weeks		Acute HBV infection
		HBeAg	4 to 6 weeks	4 to 6 years		End of acute HBV infection
		HBc IgM	2 to 12 weeks	3 to 6 months		Acute HBV infection
		HBcAb-Total	3 to 12 months	for life		Recovery, or previous infection
Hepatitis C (HCV)	Parenteral, sexual	HCV-Ag	2 to 12 weeks	persists	30 to 60-nm RNA virus	Acute or chronic infection
		HCV-IgG	3 to 4 months	2 years		past infection
Hepatitis D (HDV)	Feco-oral, sexual, and parenteral ?	HDV- Ag	1 to 3 days	3 to 5 days	36-nm RNA virus	Acute infection
		HDV-IgM	10 days	1 to 3 months		Acute infection
		HDV-Ab total	2 to 3 days	7 to 14 months		Chronic HDV infection
Hepatitis E (HEV)	Feco-oral	Anti-HEV	15 to 60 days		32-nm  RNA virus	Severe in pregnant females,

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