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Red Blood Cell (RBC):- Part 5 – Summary of RBC Morphology Interpretations and Diagnosis (Table)

October 11, 2024HematologyLab Tests

Table of Contents

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  • Summary of RBC Morphology Interpretations
        • What sample is needed for RBC Morphology Interpretations?
        • What are the indications for RBC Morphology Interpretations?
        • How will you Summarize RBC Morphology and Interpretations?

Summary of RBC Morphology Interpretations

What sample is needed for RBC Morphology Interpretations?

  • Direct blood smear or blood in EDTA can be used.

What are the indications for RBC Morphology Interpretations?

  1. To diagnose anemia.
  2. For typing of the anemia.

How will you Summarize RBC Morphology and Interpretations?

RBC morphology                       Lab findings                                 Causes                      
  • Microcytosis
Microcytic hypochromic RBC

Microcytic hypochromic RBC

  1. RBC diameter <6 µm
  2. MCV < 80 fL
  3. MCHC < 27%
  1. Iron deficiency anemia
  2. Anemia due to chronic diseases
  3. Thalassemia
  • Macrocytosis

  • RBC diameter > 8 µm
  • Megaloblastic anemia
  • Hypochromic
Mean corpuscular volume (MCV): Anemia hypochromic microcytic

Mean corpuscular volume (MCV): Anemia hypochromic microcytic

  • RBC has a central pallor area
  1. Decreased Hb contents
  2. Iron deficiency anemia
  • Poikilocytosis
RBC poikilocytosis

RBC poikilocytosis

  • RBC has variable shapes
  1. Sickle cell anemia
  2. Leukemias
  3. Microangiopathic hemolysis
  4. Extramedullary hematopoiesis
  • Anisocytosis
RBC Anicytosis

RBC Anicytosis

  • RBC has a variable size
  1. Reticulocytosis
  2. Blood transfusion into microcytic or macrocytic anemia
  • Spherocytosis
RBC spherocytes

RBC spherocytes

  1. RBC has no biconcavity
  2. RBC has no central pallor
  3. MCHC  is high
  1. Hereditary spherocytosis
  2. Loss of cell membrane relative to cell volume
  • Acanthocytosis
Peripheral blood smear: RBC acanthocyte cells

Peripheral blood smear: RBC acanthocyte cells

  • RBC has spiculated surface
  1. Liver diseases
  2. Abetalipoproteinemia
  • Elliptocytosis
Peripheral blood smear: RBC Elliptocytes

Peripheral blood smear: RBC Elliptocytes

  • RBCs are an oval
  1. Hereditary defect
  2. This is usually harmless

Possible References Used
Go Back to Hematology

Comments

Shital joshi Reply
August 5, 2021

Nice more and more know this subject

Dr. Riaz Reply
August 5, 2021

Thanks.

Abubakr Reply
March 12, 2023

Thankyou for your information

Dr. Riaz Reply
March 12, 2023

Thanks.

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