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Red Blood Cell (RBC):- Part 5 – RBC Morphology Differential Diagnosis, and Interpretations

February 22, 2021HematologyLab Tests

Sample

  • Direct blood smear or blood in EDTA can be used.

Indications

  1. To diagnose anemia.
  2. For typing of the anemia.

RBC morphology and Interpretation:

RBC morphology                       Lab findings                                       Causes                      
Microcytosis                      Microcytes RBC diameter <6 µm
MCV < 80 fl
MCHC < 27%
Iron deficiency anemia
Anemia due to chronic diseases
Thalassemia
Macrocytosis                      Macrocytes RBC diameter > 8 µm Megaloblastic anemia
HypochromicAnemia Microcytic hypochromic RBC has a central pallor area Decreased Hb contents
Iron deficiency anemia
Poikilocytosis   RBC has variable shapes Sickle cell anemia
Leukemias
Microangiopathic hemolysis
Extramedullary hematopoiesis
Anisocytosis                        Anisocytosis RBC has a variable size Reticulocytosis
Blood transfusion into microcytic or macrocytic anemia
Spherocytosis                  Spherocyte RBC has no biconcavity
RBC has no central pallor
MCHC  is high
Hereditary spherocytosis
Loss of cell membrane relative to cell volume
Acanthocytosis               Acanthocyte RBC has spiculated surface Liver diseases
Abetalipoproteinemia
Elliptocytosis                  Elliptocytes RBCs are an oval Hereditary defect
This is usually harmless
Red blood cells morphologically various shapes

Red blood cells morphologically various shapes


Possible References Used
Go Back to Hematology

Comments

Shital joshi Reply
August 5, 2021

Nice more and more know this subject

Dr. Riaz Reply
August 5, 2021

Thanks.

Add Comment Cancel


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    • Tumor marker
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