Red Blood Cell (RBC):- Part 5 – RBC Morphology Differential Diagnosis, and Interpretations February 22, 2021HematologyLab Tests Sample Direct blood smear or blood in EDTA can be used. Indications To diagnose anemia. For typing of the anemia. RBC morphology and Interpretation: RBC morphology Lab findings Causes Microcytosis RBC diameter <6 µm MCV < 80 fl MCHC < 27% Iron deficiency anemia Anemia due to chronic diseases Thalassemia Macrocytosis RBC diameter > 8 µm Megaloblastic anemia Hypochromic RBC has a central pallor area Decreased Hb contents Iron deficiency anemia Poikilocytosis RBC has variable shapes Sickle cell anemia Leukemias Microangiopathic hemolysis Extramedullary hematopoiesis Anisocytosis RBC has a variable size Reticulocytosis Blood transfusion into microcytic or macrocytic anemia Spherocytosis RBC has no biconcavity RBC has no central pallor MCHC is high Hereditary spherocytosis Loss of cell membrane relative to cell volume Acanthocytosis RBC has spiculated surface Liver diseases Abetalipoproteinemia Elliptocytosis RBCs are an oval Hereditary defect This is usually harmless Red blood cells morphologically various shapes
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