Red Blood Cell (RBC):- Part 5 – RBC Morphology Differential Diagnosis, and Interpretations
- Direct blood smear or blood in EDTA can be used.
- To diagnose anemia.
- For typing of the anemia.
|RBC morphology||Lab findings||Causes|
|Microcytosis||RBC diameter <6 µm
MCV < 80 fl
MCHC < 27%
|Iron deficiency anemia
Anemia due to chronic diseases
|Macrocytosis||RBC diameter > 8 µm||Megaloblastic anemia|
|Hypochromic||RBC has a central pallor area||Decreased Hb contents
Iron deficiency anemia
|Poikilocytosis||RBC has variable shapes||Sickle cell anemia
|Anisocytosis||RBC has a variable size||Reticulocytosis
Blood transfusion into microcytic or macrocytic anemia
|Spherocytosis||RBC has no biconcavity
RBC has no central pallor
MCHC is high
Loss of cell membrane relative to cell volume
|Acanthocytosis||RBC has spiculated surface||Liver diseases
|Elliptocytosis||RBCs are an oval||Hereditary defect
This is usually harmless