Summary of Tumor Markers

• There are specific markers for diagnosing tumors from the various organs in the human body.

Markers For thyroid tumors:

1. Calcitonin.

Markers For breast tumors:

1. CA 15-3.
2. CA 549.
3. CK-BB.
4. BRCA-1

Markers For Testicular tumors:

1. HCG.
2. AFP.
3. Calcitonin.

Markers For Prostatic tumors:

1. PSA.
2. CA 549.
3. PAP.

Markers For Bone tumors:

1. Alkaline phosphatase.

Markers For Lung tumors:

1. CA 15-3.
2. CA 549.
3. CK-BB.

Markers For Liver tumors:

1. Alkaline phosphatase.
2. AFP.
3. CA 19-9.
4. LDH.

Markers For Gastrointestinal tumors:

1. CEA.
2. CA 50.
3. CA 19-5.
4. CA 19-9
5. CA 72-4.

Markers For Colorectal tumors:

1. CEA.
2. CA 15-3
3. CA 19-9.
4. CA 50.

Markers For Ovarian tumors:

1. CA 125.
2. CA 15-3
3. CA 549.
4. CK-BB.
5. CA 72-4.

Markers For Pancreatic tumors:

1. CEA.
2. CA 50.
3. CA 19-9.
4. CA 15-3.

Monoclonal tumor markers

1. The first tumor marker was the Bence-Jones protein for multiple myeloma.
2. α – fetoprotein was discovered in 1963.
3. CEA was discovered in 1965.
4. These are defined as the presence of antigens on the tumors, which monoclonal antibodies can identify.
5. These markers are more specific and sensitive.

Monoclonal antibodies	Specific for the tumors
Free PSA	Prostatic carcinoma
CA- 15-3	Breast cancer
CA- 19-9	Pancreatic cancer
CA- 125	Ovarian cancers
CA- 72-4	Gastric cancers
CA-50	Colorectal cancer

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