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Laboratory Test Critical values, Which need immediate action

July 10, 2026Chemical pathologyLab Tests

Table of Contents

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  • Critical values
      • How will you discuss the tests and their critical values?

Critical values

  • Various tests have values that require immediate action or immediate communication of the result to the hospital or referring doctors.
Critical values: Laboratory critical value and action

Critical values: Laboratory critical value and action

  • These values should be conveyed to the concerned person without any delay.

How will you discuss the tests and their critical values?

Test  Critical value>(more than) Critical value < (less than) 
Biochemical tests
  • Amylase
Three times the normal value No value
  • Ammonia
>40 µmol/L No value
  • Bilirubin level

Adult => 12 mg/dL

Newborn= >15 mg/dL

No value
  • Blood glucose level

Adult male = >400 mg/dL

Adult female = >400 mg/dL

Newborn = >300 mg/dL

  1. Adult male =<50 mg/dL
  2. Adult female = <40 mg/dL
  3. Infants = <40 mg/dL
  4. Newborn = <30 mg/dL
  • Serum sodium (Na+)
> 160 meq/L < 120 meq/L
  • Serum potassium (K+)

Adult = > 6.5 meq/L

Newborn = >8 meq/L

Adult = < 2.5 meq/L

Newborn = <2.5 meq/L

  • Serum calcium (Ca++)
>13 mg/dL (3.25 mmol/L) <6.5 mg/dL (1.5 mmol/L)
  • Ionized calcium
>7 mg/dL (1.58 mmol/L) <2.2 (0.78 mmol/L)
  • Serum phosphate (PO4)3-
< 1 mg/dL
  • Magnesium (Mg++)
>3 meq/L <0.5 meq/L
  • Serum bicarbonate (HCO3–)
>40 meq/L <10 meq/L
  • Chloride (Cl–)
>115 meq/L <80 meq/L
  • Creatinine
>4 mg/dL (>5.0 mg/dL) No value
  • Blood urea nitrogen (BUN)
>100 mg/dL 2 mg/dL
  • Phosphorus
No value <1.1 mg/dL
  • Uric acid
>12 mg/dL
  • Triglyceride
>400 mg/dL
  • HDL

Male = <35 mg/dl.

Female = <40 mg/dl.

  • Ethanol
>300 mg/dL (>65 mmol/L)
  • Haptoglobin
No value <40 mg/dL
  • Insulin assay
>30 µU/mL
  • Arterial pH
> 7.6 < 7.2
  • pCO2
>60 mm Hg <20 mm Hg
  • pO2 (arterial)
No value <40
  • O saturation
75% or lower
  • CO2 content
<6 meq/L
  • Osmolality
>320 mOsm /Kg H2O (>600) <265 mOsm /Kg H2O
  • Haptoglobin
<40 mg/dL
  • Prealbumin
<10.7 mg/dL = Severe nutritional deficiency
  • Cardiac troponin T
>0.1 µg/L No value
  • Cardiac troponin I
>1.6 µg/L No value
  • Ck-MB
>5% or >10 µg/L No value
Cerebrospinal fluid (CSF) Critical value>(more than) Critical value < (less than)
  • Glucose
<80% of the blood level
  • Protein
>45 mg/dL No value
  • White blood cells (WBCs)
>1000/cmm No value
  • Gram stain
Positive
  • AFB stain
Positive
  • Malignant cells
Positive
  • Blast cells
Positive
Amniotic fluid
  • Bilirubin level
Increased Hemolytic anemia of the newborn
  • Color
Red, green, yellow, or brown
  • Lecithin/sphingomyelin ratio
<2.0
  • Chromosomal abnormalities
Positive
Hematology Critical value>(more than) Critical value < (less than)
  • Hemoglobin
>20 g/dL <5 g/dL
  • Methemoglobin
>40% of the total Hb
  • Hematocrit (Hct)
>60% <14%
  • Reticulocytes
> 20 %
  • Platelets
>one million/cmm <20,000/cmm
  • Total leucocyte count (TLC)
>50,000 /cmm <2000 /cmm
  • Carboxyhemoglobin (COHb)
20%
  • Prothrombin time
>20 seconds No value
  • Partial thromboplastin time (PTT)
>100 seconds No value
  • Activated partial thromboplastin (APTT)
>70 seconds
  • INR
>5.5
  • Fibrinogen
>700 mg/dL <100 mg/dL
  • Fibrinogen degradation factor (FDP)
>40 mcg/mL
  • Bone marrow
Positive for malignant cells
Urine Result 
  • Glucose
Strongly positive
  • Ketones
Strongly positive
  • Pathologic crystals
Cysteine, leucine, and tyrosine
  • WBCs
Increased number >15/HPF
  • RBCs
Increased number >10/HPF
  • Protein
Positive 2+
  • Urine colony culture numbers
>50,000 colonies/mL
Microbiology Result

  • CSF gram stain
Positive
  • Pleural fluid gram stain
Positive
  • Synovial fluid gram stain
Positive
  • Peritoneal fluid gram stain

 

Positive
  • AFB stain
Positive
  • Blood culture
Positive
  • C. Diphtheria culture
Positive
  • Peripheral blood smear
  1. Positive for malaria
  2. Positive for microfilaria
  • Respiratory area culture
Positive growth for pathogens
Hormones Critical value>(more than) Critical value < (less than)
  • TSH
> 7 mIU/L (hypothyroidism) < 0.5 mIU/L (hyperthyroidism)
  • Thyroxine (T4)

>20 mcg/dL if thyroid storm possible

Adult <2 mcg/dL if myxedema and coma

Newborn = <7 mcg/dL

  • Estriol
<40% below the average of two previous values, demand immediate evaluation of fetal well-being during pregnancy
  • Growth hormone
Peak level = <5.1 mcg/L
Surgical pathology Result 
  • Fine needle aspiration
Positive for malignant cells
  • Cervical biopsy or PAP smear
Positive for malignant cells
Serology Result
  • HBV (Hepatitis B virus)
Positive
  • HCV (Hepatitis C virus)
Positive
  • Test for syphilis
Positive
  • Coomb’s test direct /indirect
Positive
Therapeutic drugs level Result
  • Acetaminophen
>150 µg/mL
  • Salicylates
>700 µg/mL
  • Gentamicin
>12 µg/mL
  • Chloramphenicol
>50 µg/mL
  • Tobramycin
>12 µg/mL
  • Quinidine
>10 µg/mL
  • Primidone
>24 µg/mL
  • Theophylline
>25 µg/mL
  • Phenytoin
>40 µg/mL
  • Digoxin
>2.5 ng/mL
  • Digitoxin
>35 ng/mL
  • Lithium
2 meq/L
  • Lidocaine
9 µg/mL

Possible References Used
Go Back to Chemical pathology

Comments

Dr.Zahidi Reply
August 12, 2020

Very informatve

Dr. Riaz Reply
August 12, 2020

Thanks.

Dr.Zahidi Reply
August 12, 2020

Very informatve

Dr. Riaz Reply
August 12, 2020

Thanks.

Shivaputra patil Reply
May 22, 2023

Thanks, it’s beneficial

Dr. Riaz Reply
May 22, 2023

Thanks.

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