Tumor Marker:- Part 2 – Markers for Various Organs tumors and Monoclonal markers

• There are specific markers for the diagnosis of tumors from the various organs in the human body.

For thyroid tumors:

1. Calcitonin.

For breast tumors:

1. CA 15-3.
2. CA 549.
3. CK-BB.
4. BRCA-1

For Testicular tumors:

1. HCG.
2. AFP.
3. Calcitonin.

For Prostatic tumors:

1. PSA.
2. CA 549.
3. PAP.

For Bone tumors:

1. Alkaline phosphatase.

For Lung tumors:

1. CA 15-3.
2. CA 549.
3. CK-BB.

For Liver tumors:

1. Alkaline phosphatase.
2. AFP.
3. CA 19-9.
4. LDH.

For Gastrointestinal tumors:

1. CEA.
2. CA 50.
3. CA 19-5.
4. CA 19-9
5. CA 72-4.

For Colorectal tumors:

1. CEA.
2. CA 15-3
3. CA 19-9.
4. CA 50.

For Ovarian tumors:

1. CA 125.
2. CA 15-3
3. CA 549.
4. CK-BB.
5. CA 72-4.

For Pancreatic tumors:

1. CEA.
2. CA 50.
3. CA 19-9.
4. CA 15-3.

Monoclonal tumor markers

1. The first tumor marker was the Bence-Jones protein for the multiple myeloma.
2. α – fetoprotein discovered in 1963.
3. CEA  discovered in 1965.
4. These are defined as the presence of antigens on the tumors which can be identified by monoclonal antibodies.
5. These markers are more specific and sensitive.

Monoclonal antibodies	Specific for the tumors
Free PSA	Prostatic carcinoma
CA- 15-3	Breast cancer
CA- 19-9	Pancreatic cancer
CA- 125	Ovarian cancers
CA- 72-4	Gastric cancers
CA-50	Colorectal cancer

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